Totally PWN'd by Total Security

My media pc just got completely owned by Total Security.  I am now in the process of fixing it.  I am not even really sure how I got it.  Probably from this SuperNZB program I was download to repair some rars.  I am not going to link to it obviously since I don't want to help spread this thing.  This is really a bitch to get rid of.  The trojan seems to shutdown any antivirus software I try to run.  I may need to drop into SafeMode and try MalWareBytes again.

Arrgh!

Any tips on slaying this beast would be much appreciated.